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Miguel Madrid-Mencía

Senior Backend & Cloud Engineer | Bioinformatics & AI Systems

Toulouse, France · miguel.madrid.mencia@gmail.com

10+ years building cloud-native systems across genomics, healthcare, and AI. 1 first-author and 6 co-authored peer-reviewed publications with 127+ citations.

Experience

Egen.ai — Senior Backend & Cloud Engineer

Jan 2025 – Present

Hybrid: US, France

Applied ML Systems. Technology services through cloud, data, AI, and platforms. (Acquired from Qarik Group Jan 2025 — role and scope were continuous across the acquisition.)

  • Architected a multi-agent AI orchestration system on GCP for a pharma R&D client, applying genomics domain knowledge to shape agent design.
  • Developed GCP Agents and A2A orchestration via MCP/ADK for pharma and biotech clients.
  • Built an automated data pipeline migration tool with an internal developer API for healthcare and precision medicine workloads on GCP.
  • Built a Twilio-based testing framework to automatically generate all mood and user behavior call combinations for a Voice AI system, replacing manual script configuration.
  • Hardened CI/CD pipelines, code quality gates, and security standards for a US financial client — catching production issues earlier and reducing error-prone contributions across the team.

Qarik Group — Senior Backend & Cloud Engineer

Feb 2024 – Dec 2024

Hybrid: US, France

GCP-focused cloud consultancy. Acquired by Egen.ai in Jan 2025; role and projects were continuous across the acquisition.

  • Delivered an API for data ingestion into BigQuery, deployed on GCP with Terraform and Concourse, for a US biotech client.

Illumina, Inc. — Senior Software Engineer

Mar 2022 – Feb 2024

Hybrid: UK, France

Genetic analysis technologies: personalized medicine, disease research, drug development.

  • Evaluated privacy-preserving data sharing solutions to reduce friction from restrictive genomic data policies.
  • Built machine learning pipelines on Illumina Connected Analytics (ICA), HPC, and AWS.
  • Designed and optimized Snowflake-based data models for genomics and GWAS pipelines.
  • Co-authored a pending patent in applied bioinformatics and genomic data processing.

Cancer Research Center of Toulouse (CRCT) — Bioinformatics Engineer

Oct 2018 – Feb 2022

Hybrid: Toulouse, France

Translational cancer research center in Toulouse, focused on oncology and systems biology.

  • Designed reproducible ML pipelines for multi-omics analysis of pancreatic and lung cancer, scaled across cancer types.
  • 1 first-author and 6 co-authored peer-reviewed publications with 127+ citations in oncology and systems biology.
  • Built GARDEN-NET, a web tool for 3D chromatin interaction analysis, still in active use — published in Nucleic Acids Research.

Spanish National Supercomputing Center (BSC) — Research Engineer

Jul 2017 – May 2018

Barcelona, Spain

European HPC center hosting the MareNostrum supercomputer.

  • Developed a platform for AQuAS to analyze health outcomes and quality indicators through an interactive geospatial map.
  • Built the OpenEBench embeddable benchmarking widget (sole author) — a d3.js radial arc widget used by scientific tools across the ELIXIR European benchmarking platform.
  • Primary contributor (79 of 110 commits) to the OpenEBench submission infrastructure — Docker sample containers, Nextflow pipeline generator, Vagrant multi-service VM, and SFTP submission service.

Spanish National Cancer Research Center (CNIO) — Research Technician

May 2016 – Jun 2017

Madrid, Spain

Spain's national cancer research institute, focused on molecular oncology.

  • Developed a reproducible workflow to identify mutation clusters in protein structures, including web-based visualization.
  • Contributed to the European OpenMinTeD NLP/text-mining project, developing services and APIs for biomedical text analysis.

Education

Master in Master in Bioinformatics and Computational Biology

Sep 2015 – May 2016

Instituto de Salud Carlos III

Master's Thesis: Structure-PPi v2.0: Module for Annotating Cancer-Related Single-Nucleotide Variants at Protein-Protein Interfaces.

Bachelor in Computer Engineering (Information Technologies)

Oct 2011 – Sep 2015

Universidad Complutense de Madrid

Bachelor's Thesis: Computer Vision Adapted to Optical Coherence Tomographies.

Certifications

Teaching

NLP & Text Mining for Bioinformatics

Apr 2017 – May 2017

Guest Lecturer · Instituto de Salud Carlos III

Designed and delivered a 15-hour intensive module on biomedical text mining and NLP for the Master in Bioinformatics and Computational Biology (Madrid).

  • Large-scale literature extraction from PubMed and PMC via the NCBI Entrez API (BioPython, ESearch, EFetch).
  • NLP pipelines in Python/NLTK: tokenization, POS tagging, n-grams, inverted indexing, lemmatization, and stemming — adapted for bioinformaticians with varied programming backgrounds.

Publications

7 papers · 1 first-author 127+ citations h-index 7 · i10-index 6 1 pending patent · Illumina
Low replicative stress triggers cell-type specific inheritable advanced replication timing · International Journal of Molecular Sciences, 2021 · Cited by 10
Machine learning pipeline for genome-wide association studies · United States Patent Application US20240120024A1, 2024 · Pending

Skills

Cloud & Platforms

Terraform GCP AWS Kubernetes / Helm Docker, Podman CI/CD (Concourse, Jenkins, GitHub Actions)

Data Analysis & ML

Python (Pandas, Polars, Scikit-Learn) R (Tidyverse, Tidymodels, DESeq2) SQL (Snowflake, BigQuery, PostgreSQL) Generative AI / LLMs Visualization (Seaborn, ggplot2, Dash, D3.js)

Bioinformatics

Workflow managers (Nextflow, Snakemake) GWAS (Hail, Regenie, Plink) Genome Databases (Ensembl, UCSC, GENCODE, TCGA) Pathways (Reactome, KEGG, GSEA) Structural Bioinformatics Somatic Mutation Analysis (COSMIC)

Open Source

NixOS/nixpkgs: 329 merged commits (2016–2026) · package maintainer Julia, Crystal, Nim upstream PRs 13 tooling contributions (FluxML, BioJulia, fzf, and others)

Languages

Spanish (Native) English (Professional Working Proficiency) French (Professional Working Proficiency)

Certifications

GCP Certified Partner Specialist: Gemini Enterprise Deployment (Dec 2026) GCP Certified Partner Specialist: Gemini Enterprise Agent Development (Dec 2026) GCP Skill Badges: ADK Agents, Vertex AI, Kubernetes, Terraform (×9) Linux Foundation: Open Source Technical Documentation, Remote Work at Scale
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