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Miguel Madrid-Mencía

Backend & Cloud Engineer · Genomics & Applied ML

Toulouse, France · miguel.madrid.mencia@gmail.com

10+ years across research, genomics, and cloud engineering. 1 first-author and 6 co-authored peer-reviewed publications with 135+ citations. Contributed to a pending patent in applied bioinformatics and genomic data processing.

Experience

Egen.ai — Senior Backend & Cloud Engineer

Jan 2025 – Aug 2026

Hybrid: US, France

Applied ML Systems. US cloud and AI consultancy. Acquired from Qarik Group in Jan 2025 — role and scope were continuous across the acquisition.

  • Built a multi-agent AI orchestration system on GCP for a pharma R&D client, applying genomics domain knowledge to shape agent design.
  • Developed GCP Agents and A2A orchestration via MCP/ADK.
  • Built a Twilio-based testing framework to automatically generate all mood and user behaviour call combinations for a Voice AI system, replacing manual script configuration.
  • Hardened CI/CD pipelines, code quality gates, and security standards for a US financial client — reducing production incidents.

Qarik Group — Senior Backend & Cloud Engineer

Feb 2024 – Dec 2024

Hybrid: US, France

GCP-focused cloud consultancy. Acquired by Egen.ai in Jan 2025; role and projects were continuous across the acquisition.

  • Delivered an API for data ingestion into BigQuery, deployed on GCP with Terraform and Concourse, for a US biotech client.

Illumina, Inc. — Senior Software Engineer

Mar 2022 – Feb 2024

Hybrid: UK, France

Cloud genomics platform (Illumina Connected Analytics) and personalized medicine.

  • Benchmarked privacy-preserving data-sharing approaches (homomorphic encryption vs. synthetic data) for the Illumina Connected Analytics platform.
  • Built ML pipelines for genomics and GWAS on the Illumina Connected Analytics platform.
  • Contributed to a pending patent in applied bioinformatics and genomic data processing — built the Hail/Python variant data-processing layer behind the ML model.

Cancer Research Center of Toulouse (CRCT) — Bioinformatics Engineer

Oct 2018 – Feb 2022

Toulouse, France

Translational cancer research center (INSERM). Network biology, epigenomics, and cancer multi-omics.

  • Built reproducible Snakemake ML pipelines processing multi-omics datasets (RNA-seq, DNA methylation, 3D chromatin) across multiple cancer cohorts.
  • 1 first-author and 6 co-authored peer-reviewed publications with 135+ citations in oncology and systems biology.
  • Built GARDEN-NET, a web tool for 3D chromatin interaction analysis — published in Nucleic Acids Research.

Spanish National Supercomputing Center (BSC) — Research Engineer

Jul 2017 – May 2018

Barcelona, Spain

European HPC center hosting MareNostrum. Life Sciences department.

  • Developed a geospatial visualization platform for AQuAS to analyse health outcomes and quality indicators across Catalonia.
  • Built the OpenEBench embeddable benchmarking widget (sole author) — a d3.js radial arc widget used by scientific tools across the ELIXIR European benchmarking platform.
  • Primary contributor (79 of 110 commits) to the OpenEBench submission infrastructure — Docker sample containers, Nextflow pipeline generator, Vagrant multi-service VM, and SFTP submission service.

Spanish National Cancer Research Center (CNIO) — Research Technician

May 2016 – Jun 2017

Madrid, Spain

Spain's national cancer research institute. Structural biology and molecular oncology.

  • Developed a reproducible workflow (Structure-PPi v2.0) to identify mutation clusters at protein-protein interfaces, including web-based visualization.
  • Built REST API services for the European OpenMinTeD biomedical text-mining platform, wrapping NLP tools as standardized web services.

Education

Master in Master in Bioinformatics and Computational Biology

Sep 2015 – May 2016

Instituto de Salud Carlos III

Master's Thesis: Structure-PPi v2.0 — Annotating Cancer-Related Single-Nucleotide Variants at Protein-Protein Interfaces.

Bachelor in Computer Engineering (Information Technologies)

Oct 2011 – Sep 2015

Universidad Complutense de Madrid

Bachelor's Thesis: Computer Vision Adapted to Optical Coherence Tomographies.

Certifications

Teaching

Text Mining for Bioinformatics

Apr 2017 – May 2017

Guest Lecturer · Instituto de Salud Carlos III

Designed and delivered a 15-hour intensive module on biomedical text mining and NLP for the Master in Bioinformatics and Computational Biology (Madrid).

  • Large-scale literature extraction from PubMed and PMC via the NCBI Entrez API (BioPython).
  • NLP pipelines in Python/NLTK: tokenization, POS tagging, n-grams, inverted indexing, lemmatization — adapted for bioinformaticians with varied programming backgrounds.

Publications

7 papers · 1 first-author 127+ citations h-index 7 · i10-index 6 1 pending patent · Illumina
Low replicative stress triggers cell-type specific inheritable advanced replication timing · International Journal of Molecular Sciences, 2021 · Cited by 10
Machine learning pipeline for genome-wide association studies · United States Patent Application US20240120024A1, 2024 · Pending

Skills

Cloud & Infrastructure

GCP (BigQuery, Vertex AI, Cloud Run) AWS (EC2, S3) Terraform CI/CD (Concourse, Jenkins, GitHub Actions) Docker, Singularity, Kubernetes / Helm

Backend & Data Engineering

Python (FastAPI, Flask, Pandas, Polars) R (Tidyverse, Tidymodels, Bioconductor) SQL (BigQuery, Snowflake, Postgres) Go, Rust, TypeScript, Crystal, Ruby REST APIs, gRPC

ML & AI

Scikit-Learn, PyCaret, Tidymodels Vertex AI, Gemini, GPT-4o NLP: NLTK, SpaCy, biomedical NER

Bioinformatics

Nextflow, Snakemake GWAS (Hail, Regenie, Plink) Transcriptomics (DESeq2, Salmon, Seurat) 3D chromatin / Hi-C (HiCcompare, ChromHMM) Pathway enrichment (Reactome, KEGG, GSEA)

Open Source

NixOS/nixpkgs: 329 merged commits (2016–2026) · package maintainer Julia, Crystal, Nim upstream PRs 13 tooling contributions (FluxML, BioJulia, fzf, and others)

Languages

Spanish (Native) English (Professional) French (Professional)

Certifications

GCP Certified Partner Specialist: Gemini Enterprise Agent Development (Dec 2026) GCP Certified Partner Specialist: Gemini Enterprise Deployment (Dec 2026) GCP Skill Badges: ADK Agents, Vertex AI, Kubernetes, Terraform (×9) Linux Foundation: Open Source Technical Documentation, Remote Work at Scale
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