Cytidine deaminase resolves replicative stress and protects pancreatic cancer from DNA-targeting drugs
Published in Cancer Research, 2024
We demonstrate that Cytidine Deaminase (CDA) is overexpressed in pancreatic cancer and plays a crucial role in resolving replicative stress. High CDA levels correlate with resistance to DNA-damaging drugs, suggesting that targeting CDA could sensitize pancreatic tumors to chemotherapy.
Recommended citation: Lumeau, A., Bery, N., Francès, A., Gayral, M., Labrousse, G., Ribeyre, C., ... Madrid-Mencía, M., ... & Cordelier, P. (2024). "Cytidine deaminase resolves replicative stress and protects pancreatic cancer from DNA-targeting drugs." Cancer Research, 84(7), 1013-1028.
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