STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells
Published in Nucleic Acids Research, 2021
STAG2 is a major bladder tumor suppressor. This study analyzes how STAG2 loss-of-function affects genomic architecture and gene expression in bladder cancer cells, revealing distinctive distributions and interactions compared to STAG1. The findings link STAG2 inactivation to a shift from luminal to basal transcriptional programs, offering insights into bladder cancer progression.
Recommended citation: Richart, L., Lapi, E., Pancaldi, V., Cuenca-Ardura, M., Carrillo-de-Santa Pau, E., Madrid-Mencía, M., ... & Real, F. X. (2021). "STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells." Nucleic Acids Research, 49(19), 11005-11021.
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